5-1) 8-HYDROXYGUANINE, A DNA ADDUCT FORMED BY OXYGEN RADICALS : ITS IMPLICATION ON OXYGEN RADICAL-INVOLVED MUTAGENESIS/CARCINOGENESIS
نویسندگان
چکیده
منابع مشابه
Biochemistry of Oxygen and Its Free Radicals
Thrombolytic treatment in acute myocardial infarction achieves coronary patency in most patients.' Mortality in groups treated early after the onset of symptoms is significantly reduced,' but left ventricular function does not always improve.5 Myocardial necrosis during the period of vessel occlusion is partly responsible for the irreversible ventricular impairment that occurs even when the ves...
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Many previous reports using experimental animal models of pancreatitis have suggested that oxygen free radicals play an important part in initiation and development of pancreatitis. Infiltration of inflammatory cells--that is, neutrophils, lymphocytes, and monocytes--has been seen in damaged pancreatic glands of animal models and patients with pancreatitis. As neutrophils are known to be the hi...
متن کاملMutagenicities of 8-hydroxyguanine and 2-hydroxyadenine produced by reactive oxygen species.
Oligodeoxyribonucleotides containing 8-hydroxyguanine and 2-hydroxyadenine, purine lesions produced in cells by reactive oxygen species, were synthesized and inserted into vector DNAs to introduce each lesion at a predetermined site. The manipulated DNAs were transfected into living cells, and the mutants induced by each DNA lesion were collected and analyzed. In addition, the mutations induced...
متن کاملOxygen radicals and signaling.
Recent evidence suggests that reactive oxygen species, such as superoxide anions and hydrogen peroxide, function as intracellular second messengers. This review will discuss the progress in understanding the intracellular pathways leading from ligand stimulation to the generation of oxidants, as well as some of the increasing number of cellular processes that appear to be subject to redox regul...
متن کاملDevelopment of a Method for measuring Reactive Oxygen Radicals Levels In Vitro and Study the Effects of Vitamin C and E on Radical Production Reaction
Background: Free radicals and reactive oxygen species(ROS) are the most important factors in formation of oxidative stress reaction. Now, radical damage has been suggested to contribute to a wide variety of diseases such as Alzheimer, atherosclerosis and cancer. Transition metal ions in the presence of the various biomolecules produce these active compounds. The aim of this study is introducing...
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ژورنال
عنوان ژورنال: The Journal of Toxicological Sciences
سال: 1991
ISSN: 0388-1350,1880-3989
DOI: 10.2131/jts.16.supplementi_95